Begins with a late-night talk show celebrating “four years with the Fantastic Four” with a retrospective of their origin and adventures so far. The FF are supposed to attend, but can’t as they’re busy fighting Red Ghost (John Malkovich) and his super-apes.
Paul Walter Hauser plays Mole Man, the FF’s first villain who lives in the underground kingdom of Subterranea. He’s not actually a bad guy and helps them save the world in the end.
Silver Surfer arrives on Halloween night. Sue is pregnant at this point. The FF confront her in the Fantasticar and her first lines are “I herald his beginning, I herald you end, I herald Galactus.” Johnny tries to chase her but she flies into space where he can’t flame on due to lack of oxygen.
The FF go to space to confront Galactus. Sue goes into labor and baby Franklin is born. He has a rare “genetic anomaly” that gives him god-like molecular manipulation powers. Galactus offers to spare Earth if the FF give Franklin to him, as he plans to use Franklin’s power to revive his dead universe, but the FF naturally refuse.
Earth’s population actually turns on the FF because they refuse to give up Franklin, and at one point they storm the Baxter Building and beat up the FF’s robot assistant H.E.R.B.I.E.
Natasha Lyonne plays Sharon, a woman who hides Sue and baby Franklin when they go on the run. Mole Man shelters them at Subterranea, and Sharon later convinces him to send his Moloids to rescue the population and hide them in Subterranea while the FF fight Galactus on the surface.
The FF defeat Galactus in the end with Silver Surfer’s help, and ride off into the sunset as the public cheers for them. Mole Man and Sharon get together.
Ends one year later with the same late-night talk show celebrating “five years with the Fantastic Four”. The FF are supposed to attend, but again they can’t because they’re busy saving the world.